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Stefansson: "Let's look at the evolutionary role of insulin. - There are a few tissues in our body that actually prefer to burn sugar; that's our RBC's, our retinas, and certain tissues in our gonads. The rest of the body would prefer to burn fat. - We have one hormone to lower blood sugar – that's insulin. We've got a bunch of them to raise blood sugar. I maintain that it was actually increasing blood sugar that was our main problem."


Insulin: Its Crucial Role in Chronic Illness
"This talk was given in 1995, and it is quite surprising that it is still new information today. It has long been said by experts in the field that Dr. Rosedale is a pioneer and at least 10 years ahead of the curve."
The original article can be read here.

Insulin: Its Crucial Role in Chronic Illness
By Ron Rosedale, M.D.
from Ron Rosedale's blog

Published: April 2, 2013

Dr. Ron Rosedale:
Thank you for the privilege of speaking. ...
The reason actually that I am speaking is that John asked me to, after the last AAEM meeting, and a very prominent speaker lectured on merits of a high carbohydrate diet. At the end of the talk, during the question-answer period, John got up, asked a reasonable question, "What about insulin?" The lecturer, who has written multiple books, basically just derided John, and said that he just hadn't been keeping up the with the literature. This started a little bit of a heated discussion that went back and forth, and John knew of my interest in insulin for a long time.

First, let's just take a look at what the literature has to say.
So, what about insulin?

A carbohydrate diet is currently the diet of choice by the American Heart Association, The American Diabetes Association, The American Cancer Association, most weight loss experts, most nutritionists, and also, I should say, most sports physiologists. Carbo-loading is almost gospel in sports.

Let's talk a little bit about hyperinsulinemia, because a high carbohydrate diet certainly causes high insulin levels. Hyperinsulinemia adversely affects almost all degenerative diseases. That includes coronary artery disease, hypertension, cancer, stroke, diabetes, of course, obesity, autoimmune disorders, and mental disease and decline. In fact,
I think you'll come to know, and it is not just my opinion, that it may be the chemical mediator of all of the degenerative diseases of aging. It may be the leading killer in our society. We are going to discuss what it is, what causes it, and why.

First, let's just look back at other populations.
They have already tried a number of different diets; let's see what happened to them. Going way back let's talk about agriculturalist, and hunter/gatherers. Anthropologists can almost immediately identify a particular society of people when they do diggings, and dig up a bunch of bones. They know almost immediately whether that society was considered a hunter/gatherer, or whether they were considered agriculturalists. Agriculturalists grew grains, and they grew their food, where the hunter/gatherers lived mostly on meat. The bones, if they are nice and strong, and long, and if the teeth are in very good repair, and if the skeletons generally showed a large body-build, those are almost uniformly hunter/gatherers. The agriculturalists have much shorter bones, and their bones are much weaker. So, the assumption, and generally being very correct, is that the hunter/gatherers were the much healthier of the people.

Let's talk about the Egyptian diet. Now, the Egyptians are kind of unique, in that they left an excellent record. There are considered to be more mummies than there are currently Egyptians, and many of these were preserved very well. Mummifying was probably the ultimate antioxidant. What did they eat? There are multiple records in the papyrus writings, and in the examinations of the digestive systems of the Egyptians were very excellent documentations of the diets of the ancient Egyptians.
What was it? Well, they ate a lot of fresh vegetables. They ate a lot of lettuce, cucumbers, garlic, onion, lentils, peas, and they used a lot of olive oil. The only oils they essentially used for cooking were olive oil and sesame oil. They used no lard. They ate a lot of bread, and the bread was made by freshly stone-grinding wheat and barley.
There were no processed foods; they didn't have cans then. They used a little bit of honey, and no refined sugar; obviously, they didn't have refined sugar then; that didn't come for another thousand years. They ate no red meat. They ate a little bit of fish, they ate some chicken, and of course, it was free-range chicken.
They ate a very low-cholesterol diet, and a very low-saturated fat diet. Does this diet sound familiar? Sounds like a diet that was previously recommended in this mornings talk as being a very excellent and healthy diet. I mean, you couldn't go into a health food store and buy that good a diet.

So, what was the health of these people like? Well, a gentleman by the name of Iden Cogburn, who is the founder of the Paleopathology Association (this is a group of pathologists and other physicians who are very interested in studying scientifically the remains of ancient societies), wrote a book called MUMMIES, DISEASE, AND ANCIENT CULTURES. I'd like to quote him:
"Atheromatous disease of the arteries is a common finding in mummies. Nowadays, a great deal of emphasis is placed on the stress of modern life. Once modern diet is factored in the high incidence of this disorder in our present-day industrialized civilization, but the etiological influences were certainly there in the ancient world, and this thought should be taken into account in any theorizing regarding causation."

It is well known that ancient Egyptians had a very high incidence of coronary disease. In analyzing the arteries, and they had a high incidence of calcified plaque in the arteries, and these people did not live long. They died young; even at a young age, their plaque was highly calcified, indicating it had been there for a while.
We also know that they had hypertension, and they had rampant obesity. These people were not thin like you see in writings. Now of course, when we take pictures in magazines, we only take pictures of beautiful, live models. The ancient Egyptians were actually an obese society.
They also had very poor dental hygiene. They had a lot of infection, a lot of parasites, and they were not a healthy society, and yet, they ate a diet that would be the choice of diet that is currently recommended. The diet that the Egyptians ate, and the diet that is currently recommended, is a high-carbohydrate diet. Now, their diet was a very high complex carbohydrate diet; there was nothing refined at all about it, yet they were not very healthy. This is uniformly found in ancient cultures.

I would also like to take a look at the Eskimos. The Eskimos eat a diet that for most people would be considered horrendous. Anywhere between 70 to 90% of the calories derived in Eskimo diets are from fat, depending on the season. Sometimes they will eat a high-protein diet, high protein or fat. They eat very little carbohydrates. In wintertime, they eat no carbohydrates. Coronary disease is almost unknown; so is diabetes. Look it up!

In the last, well, especially 15 years, but even 20 or 30 years, our consumption of fat has declined. You cannot go into a grocery store anymore without seeing row after row of nonfat foods. We've got nonfat Fig Newtons, nonfat cheese cake, and nonfat everything – fat has gone down, I mean, Snackwell's from Nabisco is one of the hottest companies, nonfat cookies.
What's happening to us? In a very short period of time, in the last 12 years, the incidence of clinical obesity, which is considered 20% over ideal weight by the Metropolitan Life Insurance tables, has gone from 25% to 33%. We're the fattest country on earth. So, if the fat consumption has gone down, our fat has gone up. We are substituting the fat calories for carbohydrate calories.

Well, let's talk about insulin.
Insulin really is the master hormone of metabolism. It tells our energy where to go, and what to do, and how to do it. It regulates our energy intake. When you're talking about obesity, and when you're talking about anything that has to do with fat, or coronary disease, you cannot ignore insulin. It's there to tell that fat where to go, and how to get there. Of course, we know it is made in the pancreas, in the beta cells of the islet cells of the pancreas, it is initially stored as granules, and those granules are released when there is a sensation of blood sugar, and that quick release is lost in type II diabetes. I'll kind of breeze over this; I don't want to dwell too much on some of this. One thing I do want to mention is, in the molecule itself, there is a small peptide called C-peptide, and that C-peptide is cleaved when it is released into the blood stream. You can use that little peptide to determine how much insulin a pancreas is putting out. So, if you have a patient who is on insulin, how can you tell if their own pancreas is working? How much insulin are they actually manufacturing themselves, without getting poisoned by exogenous insulin? Well, you can measure the C-peptide level, and you can know whether they are producing their own insulin or not. That is a very important test, because that is going to tell you ultimately whether that person really needs to be on insulin or not.

Let's look at the evolutionary role of insulin.
Why is insulin really there? You talk about insulin, and you think about decreasing blood sugar, and insulin is there to lower blood sugar. I wasn't around at the time, but I don't think that was really the reason that insulin came about. I mean, insulin really came about to manufacture, and to regulate energy. Way back when, I don't think lowering blood sugar was a major problem; there wasn't that much of it. There wasn't much carbohydrate out there; nobody had sugar. Nobody ate Twinkies. We have one hormone to lower blood sugar – that's insulin. We've got a bunch of them to raise blood sugar. I maintain that it was actually increasing blood sugar that was our main problem. Our brain burns glucose. There are a few tissues in our body that actually prefer to burn sugar; that's our RBC's, our retinas, and certain tissues in our gonads. The rest of the body would prefer to burn fat, but it is due to the tissue's requiring glucose that we need to maintain a certain level of blood sugar, and so we have developed multiple hormones to keep the sugar up, if we are not taking in very much carbohydrate, which, millions of years ago, just wasn't there.

Let's talk quickly about glucose homeostasis. You eat sugar, you eat carbohydrates, cause an increase in blood sugar, at least to the release of insulin from the pancreas, and the production of the insulin in the pancreas, which is important. That goes right to the liver, which shuts off hepatic gluconeogenesis. That is a very important concept. One of the main effects of insulin is to turn off the liver's production of glucose, and we will get to that a little bit later, too.

The sugar goes to the receptors throughout the body, especially fat and muscle cells, and that stimulates the number of reactions which cause glucose uptake and utilization, glycogen synthesis, and then decreased serum glucose, straight forward. Now, what happens when you have a high-carbohydrate meal? That causes the output of quite a bit of insulin. This causes a lot of large numbers – large numbers, large mistakes. You eat a bunch of carbohydrates, this forms a bunch of blood sugar, and your pancreas senses that you've got a very high blood sugar level, so it just dumps all those insulin granules, to try and get that blood sugar stored. That can cause generally an overshoot, and the sugar goes a bit too low.
Now, what happens? Your body puts out the multitude of regulatory hormones to increase blood sugar that has evolved over the years, many years ago. Glucagon, and in particular cortisone, epinephrine, and growth hormone, to some extent. That is a frequent cause of stress.

It's probably your main stress: the constant stress on the adrenal to produce cortisone to raise your blood sugar after it has gone too high, and then too low. It goes up and down and up and down, and it's a constant cycle that we are going through all day long. It has multiple repercussions. In addition, we still have quite a bit of insulin out there. Now, that insulin is turning off the production of sugar, and it signals the brain when that sugar is low, to crave sugar and carbohydrates. When your levels drop, one of the main effects is that you crave carbohydrates to get that sugar back up. This is one of the main causes of sugar craving. What happens, you'll go for that nearest bag of potato chips you can. What happens? Blood sugars go way up again, and we repeat the cycle, day in and day out, week after week, year after year.

Glucagon – you don't hear much about Glucagon. Glucagon is also manufactured in the pancreas, right next to where insulin is manufactured, in the alpha cells. This essentially has the opposite effect of insulin. It stimulates the burning effect, it stimulates the breakdown of glycogen to increase blood sugar, it stimulates gluconeogenesis, the manufacturer of sugar from amino acids, and it increases your blood sugar, and it is secreted in response to eating proteins, and not carbohydrates. You never hear of alpha cell burn out. Beta cell burn out is common, as it is happening to all of us. You never hear about alpha cell burn out. Why is that?

Okay, let's talk a little about insulin physiology.
What does it do? You talk insulin, you could talk to an endocrinologist. "What does insulin do?" "It lowers your blood sugar." Yeah, but you'll see, it does a lot more. It increases fat storage and uptake through an enzyme called lipoprotein lipase. A ton of research right now is going on lipoprotein lipase; insulin turns it on. You cannot get fat without it. Lipoprotein lipase allows fatty acids to get into cells. Basically, what it does, is it takes the fatty acids from triglycerides. Triglycerides themselves cannot get right into a fat cell. It has to be broken down into fatty acids. The fatty acids then enter the adipose tissue, and then turn into fat. Lipoprotein lipase is turned on, and you get fat. It is a very important enzyme.

Insulin decreases gluconeogenesis in the liver. That is really, in a 24-hour period, how insulin lowers your blood sugar, not so much by transporting into cells. Your total amount of blood sugar in a 24-hour period is increased more by gluconeogenesis in the liver than it is by your dietary intake. The regulation of gluconeogenesis by insulin is extremely important. We'll get to that a little bit later. It increases the amino acids in the muscle tissue. Insulin is an anabolic hormone. It is a very powerful anabolic hormone! Growth hormone works very minimally without insulin. The two work together. Growth hormone and insulin allow different amino acids in the cells. Without both of them, you really cannot get a complete protein into your cells. Weight lifters are starting to recognize this, because insulin is not banned. It increases fat storage, especially visceral and abdominal, and that's very important. That is where it packs the fat. We'll talk about that in a little bit.
I don't know if you heard about the apple shape and the pear shape. Apple shape is much more detrimental to your health, especially in women. That's where you get fat belies. You get fat thighs, and you might not look so great, but you're not hurting your health as much. Insulin puts it in your belly, packs it in your liver, packs it in your kidneys, and inhibits function.

Another very important aspect; insulin decreases fat lipolysis. You cannot burn fat when insulin levels are high. It is very difficult. You try to go on a diet, and you have high insulin levels, you might lose weight, but you're not going to burn fat. You'll burn everything else that can turn to sugar, that could include your heart, first. You lose lean body tissue. You get increased saturated fat production delivered from sugar. Insulin tells your liver to make fat from your excess sugar floating around that you're not burning. Your liver gets fat. That's where fat production takes place. Another type of fat that your liver will synthesize is cholesterol. Again, insulin is an anabolic hormone; it manufactures fat, and it also manufactures the house for it. There are not enough cells to hold it, so it tells your body to manufacture more fat cells. Cholesterol is required in the manufacturing of all cells. It is an integral component of all cell membrane. So, as it is telling your body to manufacture cells, it is telling it to manufacture cholesterol. It is a very potent cholesterol synthesizer. In fact, it is by far the most potent. We'll talk about this a bit later, but if you want to lower somebody's cholesterol, pay attention to insulin, because you can do so very quickly and very powerfully. You can take cholesterol levels that were 400 or 500, and get them down to 200 in weeks if you lower a person's insulin. Cortisol becomes increased both by a direct effect of insulin, and as a secondary effect by lowering blood sugar.

Growth hormone is decreased in light of work on DHEA. We've heard a lot about DHEA recently, and how wonderful DHEA is. The only known way to increase DHEA naturally is to lower insulin. High insulin lowers DHEA. We'll show you that later. The so-called good eicosanoids are decreased, and the bad icosanoids are increased. Extremely important: Eicosanoids control so much of your body! They are the most powerful hormones known. We'll get to eicosanoids a bit later. I won't dwell on them right now. When we talk about eicosanoids, we'll talk about delta-5 desaturate. That is increased by insulin. That is one of the most important enzymes in the body, in the regulation of hormones. You're going to hear a lot about delta-5 desaturate in the future. If you regulate delta-5 desaturate, you can either be healthy, or you're going to be sick. We'll get into that. Insulin increases fluid retention, it increases the excretion of magnesium, potassium, and it increases sympathetic tone. It increases smooth muscle cell proliferation. It enhances endothelial cell production, and if there is ever a prescription for high blood pressure, that's it. Essential hypertension in many circles now is being considered as caused by insulin. Where did they get "essential hypertension?" Essential for what? You talk a lot about endothelial health, and there is a lot of work, especially by George Kindness, who spoke this morning, about platelet adhesiveness. We all know that it's really the clot that ends up actually killing us in coronary disease. When the blood is hypercoagulatable, if that' a word, you're going to be much more prone to coronary disease and stroke, and all sorts of other illnesses. It's quite well known that insulin increases platelet adhesiveness.

It increases plasminogen activator inhibitor, and increases fibrinogen. It happens when we go on a chronic high-carbohydrate diet. This is new to humans. It's an experiment. We've really been on a high-carbohydrate diet. We haven't been there, not until we started cultivating lots of grains. What was around way back when, during cave man times, or whatever you call it. There is a lot of debate; were we animal eaters, or were we plant eaters. Frankly, I don't think we cared. We just wanted to eat what was there. We ate a lot of plants. We have to examine our anatomy, the length of our intestines, our jaw, our teeth. We were somewhere between a carnivore and an herbivore. We ate both, probably a bit more toward plants because they didn't run away. They were easier to get to. We ate a lot of plants. If there was a wounded animal, we'd eat it. We didn't eat a bowl of rice. We didn't eat a big bowl of pasta. We didn't eat two loaves of bread; it wasn't there. So, now, we're eating a high-carbohydrate diet. That causes insulin resistance, and there is a lot of work being done.

How does it cause insulin resistance? You can use the analogy: If you eat a lot of salt, (you start using salt to salt your foods, you never did before, but you do now), you start burning out the taste receptors for salt. You have to use more and more of it for foods to taste salty. Pretty soon, you have to use five tablespoons of salt, whereas a pinch of salt would have tasted just as salty months ago. It's the same with sugar. Your taste receptors become desensitized. You walk into a smelly room, stay there a half an hour, and it doesn't smell. Somebody else walks in, they faint. The olfactory nerve becomes desensitized. A cell becomes resistant to insulin in the same way after constantly being bombarded with it.
There is a lot of work being done about insulin receptivity. That's why the main thrust in research now in diabetes. They know that there are a fewer number of receptors when cells are constantly bombarded with insulin. They also know that with each receptor that there is decreased signal transmission. The receptor is a very complex molecule. I'm not going to get into it, because that would be an hour's discussion right there, but there are multiple proteins involved. The insulin receptor transcends the entire membrane, and there are a number of chemical reactions that go along, — that transmit the signal into the cell. Most of them are proteins, and somehow, that receptor becomes burned out, and doesn't work as well.
You need more insulin to do the job, and you get what's called hyperinsulinemic; you have hyperinsulinemia, to maintain your blood sugar. You're not diabetic yet; your blood sugars are maintained. Your pancreas has a great capacity to put out a lot of insulin to keep that sugar down. Sometimes, it takes ten times as much, and we have seen patients who are putting out ten times as much insulin as a normal person to maintain their blood sugar. This person was not a diabetic. His fasting blood sugar was perfectly normal; he was just like you and me, but guess what? What did he see me for? Obesity. He was very big. He was young.
What are the main causes of insulin resistance? Well, again, a lot of work is being done. We're not sure what all the causes are. One thing we do know is that a chronic high-carbohydrate diet does that. One of the ways is by the chronic high blood sugar. You get what are called glycosylation of protein. We'll talk a little bit more about that later, but one of the problems of high blood sugar is that that sugar combines with proteins, and causes glycosylation, and most people here have probably heard about hemoglobin A1C. That's how you can measure long-term sugar control in a diabetic. Sugar glycosolates all proteins, and it does it to everybody, not just diabetics. If you measured your or my hemoglobin A1C, we hall have hemoglobin A1C, and all our proteins are glycosylated, and how glycosylated they are depends on how much sugar you've eaten. The insulin receptors themselves are made of of proteins, and they glycosylate, too. We'll talk a little more about about the problems with glycosylation later.

Insulin resistance.

Saturated fats are known to increase insulin resistance – well known. There you go with blood sugar again. Your liver makes saturated fats out of excess blood sugar. The type of fat that your liver makes from excess sugar is a fully saturated fat. It's not a good healthy fat; it's a sticky, unhealthy, saturated fat; the kind you were avoiding when you ate the nonfat Fig Newton, and increasing your carbohydrates, and you just manufactured that saturated fat you were trying to avoid, but in doing so, you also increased your insulin. Is there a genetic component to insulin resistance? Well, maybe, that's really under debate, too.

There was a recent study one to two months ago in Science And Medicine that showed that insulin resistance can actually begin in utero. The mother is eating a high-carbohydrate diet, eating a lot of sugar, — partial beta cell burnout in the fetus. Perhaps it's not so genetic. It is also known that low polyunsaturated fats increase insulin resistance. Supplementing with good polyunsaturated fat, omega 3, increases insulin sensitivity, and does so quite strongly. I cannot really go into the talk about fats, because there is s lot of controversy, but the controversy really arises in that fats can either be the healthiest component of your diet, or the most toxic.

Polyunsaturated fats oxidize readily. Now try to remove it. When you go into a grocery store, you cannot find a good polyunsaturated fat; they have to take it out because it oxidizes so readily; it has no shelf life. It has to be protected. Your body has a ton of mechanisms to protect the polyunsaturated fats from becoming oxidized, and that's really the main purpose of vitamin E. It's incorporated into the cellular membranes right along with the polyunsaturated fat. This is a very important concept: Polyunsaturated fats are good for you; they just have to be protected. One saying to avoid polyunsaturated fats because it can oxidize readily is like saying avoid oxygen because it can oxygenate tissues. It's crazy.

There are three main sites of insulin resistance: The liver, muscle, and fat. We're going to talk about that a little bit more, and how important that is.

What's the problem with hyperinsulinemia, insulin resistance, and why it is so bad? Well, the obvious problem is diabetes. We'll talk just a little bit about diabetes. Diabetes type I is a different story and the two diabetes are really two totally different diseases with the same name. Diabetes type I is where the beta cells are destroyed. There is a strong autoimmune component, and there are autoimmune antibodies that are floating around, and something destroys the beta cells. Nobody is sure what it is; maybe it's a virus. A lot of people implicate weak protein, but there is some sort of autoimmune reactions that is wiping out the beta cells. A true type I has very little autogenous insulin production, and that person is likely going to need insulin the rest of their life. Insulin is necessary, it's not all bad, it is an anabolic hormone. You need it for muscle systhesis.
Now, type II is a totally different story. The large majority of diabetics are type II. It is an acquired disease. It's caused by insulin resistance; it is when insulin reduction can no longer keep up with insulin resistance. Type II diabetics produce too much insulin; I should say they produce much more insulin than the non-diabetic. It's not a problem with not producing enough insulin, it's a problem with insulin resistance, as cells aren't listening, and so, the pancreas has to put out a ton of insulin to get the job done. If you want to go into details, you're considered a diabetic if your fasting blood sugar is greater than 140, or if it is greater than 200 within the first two hours of glucose tolerance testing. I'm not big on numbers, but that means that if your fasting blood sugar is 139, you're non-diabetic. Now, that increased insulin resistance causes an increase in hepatic glucose production. It's no longer inhibited by the insulin. That's very important, because the pancreas is free to churn out sugar, and continues to make a lot of sugar. It is a sugar-making factory, and does so mostly from amino acids. Again, most of the blood sugar in a 24-hour period is from hepatic production, not immediately from your diet.
One of the definitions of type II diabetes is that it is a disorder in control of gluconeogenesis normally inhibited by insulin. There is also decreased muscle and fat glucose uptake, and also not on there, there is a decrease in the amino acid uptake in muscles, when you have insulin resistance. It's very important, it gives you a fine, end-stage diabetic when the cells are no longer listening to insulin, and they cannot absorb amino acids, and they become muscle-depleted, approaching wasting.

Now, what about us in-between? Is your fasting blood sugar less than 140? Does your tolerance test never go above 200? We eat a high carbohydrate diet, our insulin levels are high, and we have what's known as impaired glucose tolerance. It's totally unknown how many people have that. It's not normally tested. You go get a checkup, and they'll check your blood sugar. A tiny fraction of physicians might test the fasting insulin. I told you, it's very little. One estimation is that a third of the elderly people, another estimation is a third of the entire population, and I heard another estimation is 2/3 of all people over 65. Anyway, a lot of us have impaired glucose tolerance. We have normal blood sugar, but we have higher and delayed insulin output.

What of the effects of increased blood sugar?
Why is that so bad? Well, short-term, it's not good because it can create an osmotic gradient in the kidney, and we pee a lot. We dehydrate, going to the bathroom all the time. We need very little insulin, actually, to prevent acidosis. That's not really a major problem for most of us. Very high blood sugars cause fatigue, mostly because of dehydration. That's the most immediate effect, but that's not the real bad effect of it. The chronic effect of constant sugar in the diet is glycosylation of proteins. Constant sugar in the diet also depletes magnesium, manganese, chromium, it depletes manganese SOD, and it also reduces receptor activity. To quote from JOURNAL OF DIABETES, 03/91, "Diabetes with complications is associated with increased chemical modification of proteins and lipids, and this damage appears to be largely oxidative in origin, and is sufficient to explain the altered function of proteins in the extra-cellular matrix."

I want to talk a little bit more about glycosylation of proteins. It affects all of our proteins, not just hemoglobin. It affects our lipoproteins. The lipoproteins become glycosylated. It's also known that when a protein becomes glycosylated, it is a much greater target for oxidation. It increases the oxidized ability of protein when sugar is attached. Sugar becomes also a sticky baggage for that protein, and the protein can no longer function properly. It is constantly having to drag that sugar around for the life of that protein. It increases the oxidized ability of glycosylated LDL. The LDL becomes glycosylated. The HDL becomes glycosylated, it cannot function properly when it is glycated. We all have known about the damage that oxidized LDL can do. Well, glycosylated LDL is extremely oxidizable.
In addition, we have sugar attached to a protein, and if there is also an attached lipid, it increases the likelihood of poor oxidation of that lipid, which also increases the oxidizability of lipoprotein. This is very important. There is an article called "The World Of Oxidative Stress and The Development of Complications of Diabetes." This is in DIABETES, Volume 40, April 1991. "There is evidence of increased oxidative damage to collagen," (which is a long-lived protein, and most of the oxidative damage of consequence is going to have the long-lived protein), "in diabetes. Because of the interplay between glycation and oxidation in their formation, we have termed these compounds glycosidation products. Because these products accumulate in collagen normally as a function of age, and at an accelerated rate in diabetes mellitus, diabetes mellitus may be legitimately described at the chemical level as a disease characterized by accelerated aging of collagen by glycative and oxidative mechanisms.

What are the consequences of hyperinsulinemia?
There are a lot of names for hyperinsulinemia. Syndrome X you might have heard about, and we call it CAOS, which stands for coronary artery disease, hypertension, hyperlipidemia, adult onset diabetes, obesity, and stroke. I just call it the IRS, insulin resistant syndrome; I'm not sure which is worse. There are extreme cardiovascular and cerebrovascular complications. This has been known for a long time. It takes a long time for information to get down the pipeline.
Inatola Cruz did what at the time was a very famous study. Most of us, and most cardiologists, and endocrinologists have totally forgotten about this. This was done in 1961, and published in the journal CIRCULATION RESEARCH. It was titled "The effect of Intra-arterial Insulin on Tissue Cholesterol, And Fatty Acids In Diabetic Dogs." They made dogs diabetics, and they infused insulin into the femoral arteries of those dogs for eight months. They sacrificed the dogs and examined them, and lo and behold, the femoral artery that had the insulin effused was covered with fatty streaks. The contralateral femoral artery was clear.

Another study was done by R. W. Stout, who is still doing a lot of research. This is published in the BRITISH MEDICAL JOURNAL IN 1970. This is entitled "The Development of Vascular Lesions In Insulin Treated Animals Fed A Normal Diet." This was done in Belfast.
"We took chickens, and we injected them with insulin for 19 weeks. We chose chickens because birds develop similar atherosclerosis as humans, and chickens in particular, because they are omnivorous. After 19 weeks, he examined their aortas, and found that there was a great increase in lipid deposits in the aortas of the insulin treated chickens as opposed to the ones who didn't have insulin. He quotes that this provides further evidence in favor of the hypothesis that insulin and atheroma are causally related." This was in 1970. He is continuing to do research, and he published another summation. This is in DIABETES CARE, 1990.

"Long-term treatment of insulin results in lipid-containing lesions and thickening of the arterial wall in experimental animals." This time, they are talking about human trials.
"Insulin often inhibits regression of diet-induced experimental atherosclerosis, and insulin insufficiency inhibits the development of arterial lesions. Insulin stimulates lipid synthesis in arterial tissue."
A quick chart, and I will not draw on it too long, but it shows the rise in incidence of coronary disease, with fasting serum insulin. One-vessel, two-vessel disease, fasting insulin rises.

Gerald Ravin is one of the pioneers in insulin resistance research, and I won't dwell too long on this, but he is talking about some of the diseases that are clustered in insulin resistance. It talks about hypertension, glucose intolerance, hyperglycemia, upper body obesity, and they found out further now that there is a – hypertension resistance to the insulin hyperinsulinemia, glucose intolerance, increased VLDL triglyceride, reduced HDL cholesterol activator inhibitor, and fibrinogen levels.

What else does it do? We just talked about hyperlipidemia, and increased cholesterol synthesis. It increases small, dense LDL particles. We go on in our research about the detrimental effects of lipids, and first it was cholesterol, and if not cholesterol, it's LDL cholesterol and cholesterol is good, and then we find that it is oxidized LDL. There is a type of LDL particle that is called a small, dense LDL particle, and that is the type of particle that is preferentially manufactured in the liver by insulin. We'll talk about that in a minute. It increases HMG coenzyme A reductase. When you lower insulin, you inhibit that. When you increase glucagon, you inhibit that. Sounds like Mevacor, only without the adverse side affects of stopping co Q-10 production, (and other enzymatic reactions in the liver). It increases LDL oxidizability, and that is very important. It decreases HDL, it increases arterial wall thickening via endothelial proliferation. It increases fluid retention, as we talked about earlier. It increases blood pressure, and it increases clot formation. It decreases natural killer cells, and it increases cancer because of that, it decreases T-helper cells. It increases sympathetic tone. It increases prostaglandin E-2. Solvetti out of ——Italy, in an article titled "The Interrelationship Between Insulin Resistance And Hypertension."

"Insulin can increase blood pressure via several mechanisms: increased renal, sodium, re-absorption, activation of sympathetic nervous system, alteration of trans-membrane, ion transport, and hypertrophy of resistance vessels. Hypertension can cause insulin resistance by altering delivery of insulin, and glucose into the muscle cells, resulting in impaired glucose uptake." You have a vicious cycle.

In ——-, by Dr. Austin, called "Low Density Lipoprotein Subclass patterns, and Risk of MI."
"The LDL subclass pattern characterized by small dense LDL particles was significantly associated with a three-fold increase risk of MI, independent of age, sex, and relative weight."
Going on in the journal CIRCULATION, in 1993, "Small dense LDL is an integral feature of the insulin resistance syndrome."

Gerald Reavin, in reviewing some of the literature titled "Syndrome X," Six Years Later, "resistance to insulin stimulated glucose uptake, the common phenomenon, occurring in approximately 25% of the population, is associated with a number of risk factors for coronary heart disease, including hyperinsulinemia, abnormal glucose tolerance, non-insulin dependent diabetes mellitus, increased plasma triglycerides, and decreased HDL, denser LDL particles, hypertension, and abnormalities of fibrinolysis."
It is hard to be healthy like that. Another important researcher, Zavaroni in Italy, JOURNAL OF INTERNAL MEDICINE, entitled "Hyperinsulinemia, or ——- syndrome X.

"Hyperinsulinemic subjects are found to be relatively glucose intolerant, have higher triglyceride and uric acid concentrations in blood pressure, lower HDL cholesterol when compared with normal insulinemic individuals, but importantly, the difference in the degree of obesity had little affect on the variables measured when individuals were matched for insulin response." In other words, it's not their obesity that's causing this. That is an important article.

Insulin causes obesity. Obesity can also lead to insulin resistance, but it isn't the obesity that is causing the hypertension, and all these other problems; it's the insulin. This is from David Belle.
"Insulin resistance, an often unrecognized problem, accompanying chronic medical disorders. Several population studies have shown that hyperinsulinemia is the independent risk factor for atheroschlerosis." I think we are figuring that out. "Insulin resistance is associated with a number of risk factors for atherosclerisis, including glucose intolerance, hypertension, and dyslipidemia. Management should include attempts to reduce insulin resistance, and certainly not increase it." Remember that! This is another article that we will get to a little bit later.
This is a very recent article, January 1996. This is a Japanese group, out of Osaka, Japan, that decided to do angiograms, and measure insulin. They put it in language that cardiologists can understand. They can understand angiograms, and anything else is a foreign language.

"In conclusion, these data suggest that in patients with coronary artery disease, insulin-medicated glucose metabolism is significantly impaired, and correlation is noted between insulin resistance and severity of coronary artery disease. Hyperinsulinemia may stimulate the artheromatous process." This is in DIABETES CARE, January 1996.

What about obesity? Insulin makes you fat. Insulin is an anabolic hormone. It is a storage hormone. Its' main purpose in life is to store energy. Another important aspect of insulin is that it inhibits lipolysis very strongly. It wants you to store that energy, and it doesn't want you to burn it. It's a protective mechanism. Food, way back when in caveman times, wasn't abundant all the time. It was feast or famine. We had a lot of it sometime, and we didn't have a lot of it sometimes, especially in the wintertime. Insulin is really developed to store that energy. It was a protective mechanism. Insulin causes an increased abdominal fat. It is an independent risk factor. Apple versus pear shape; we talked about being an independent risk factor. Insulin increases fat cell number. That is important.

The original recording and article can be found here: Ron Rosedale's blog.

Here is a testimonial from Dr. Ron Rosedale's website:


Just a bit about myself, I was 221 lbs and 5'10 at age 40. I rode my bicycle to work 30 miles a day and lifted weights but I over ate. I realized that I was not able to roll around on the floor and play with my kids and that something had to change so I started on a path to reinventing myself.
First thing I did was eliminate grains from my diet. I found an old Vince Gironda book for bodybuilders and went all meat and vegetables, eating six times a day in small portions. Tried a lot of other things but eliminating grains has been the mainstay of my diet.
I got into Fast-5 intermittent fasting about three years ago and have been able to maintain 170-173lbs now for a couple of years. But I was stuck there. I read your post on paleohacks and got your book back off the shelf. I'm still doing Fast-5 (five hour window in the evening) along with your recommendations for no more than 15-20g protein at a sitting, increasing nuts, avocados, sardines, salmon, etc, and I've dropped TEN POUNDS in three weeks! And I'm never hungry!!
I'm at 163 now and could easily lose a few more to get more ripped and muscular than I've ever been in my life. Gary Taubes had said to eat as much meat as you want and cut the carbs down as far as you can. That works for a normal person, but I want to be defined and "ripped". I was actually on ZERO carb for three months but my weight stayed at 170 and I still craved peanut butter and alcohol.
Now that I'm on your program, I'm never hungry, have no cravings, and I drink one carefully metered glass of red wine with dinner! I'm so happy! I can't believe I look so good at 45 years old!
Rick Stewart


"amazing long-lived natural doctor!"


My First Water Fast
I was startled by the statement that all colds, fevers and influenzas were nature's attempt to free the body of disease. I devised an experiment to test this - click here
Fruit - Friend or Foe?
He lived on nothing but grapes - By the 32nd day, his gum was bleeding - one of his teeth fell out. He exclaimed: My God, I am detoxicating my teeth - click here
Symptoms to Expect when Improving Your Diet
This initial letdown lasts about ten days, and is followed by an increase of strength, a feeling of diminishing stress and greater well-being. - click here
How Diseases are Cured
Dr. Shelton: - It is high time to learn about the causes of disease and of the "complications" that so frequently develop under regular care - click here
The Time-factor in Recovery
Dr. Shelton: - Why do we expect to get well in a hurry of a condition that requires a life-time for its development? - click here
Sequential Eating
Any quick digesting foods must wait till the slowest digesting foods leave the stomach - a process which can take up to 6 or 8 hours. - click here
How Important is Diagnosis?
Once the truth of how to live is understood, the process of illness can be reversed more or less painlessly by intelligent living - click here
How to Live 100 Years
If you follow a minimal diet you can achieve super nutrition. Let's look at Luigi Cornaro, who at age 35 was weak, sick, and dying - click here


How to Solve Problems
The following method, ancient in its origin, has been practiced by several civilizations dating back for thousands of years. - click here
Causes of Addiction to Habits
The key which unlocks the mystery of why most habits are difficult to break lies in the understanding of the stimulation and depression mechanism. - click here
How to Overcome Temptations
The very moment an undesirable craving has entered your consciousness, DON'T struggle with it. Absolutely REFUSE to consider its existence - click here
Attentive Eating
A subject which can radically change a person's life in all of its aspects - physically, mentally, emotionally and spiritually. - Attentive eating. - click here
Energy in the Body
The lift we get from drinking coffee, or the expression of strong emotions - is the expenditure of energy, not its accumulation - click here
Energy, Feeling and Thought
The person who feels depressed or negative most of the time is low on the energy level scale and needs to increase rest and sleep - click here
The Energy Principle in Healing - New Concepts
All healing and regeneration is in ratio to the amount of energy which is available - the more energy, the more detoxicating healing - click here


Three Generations of Hygienists
These children, the skeletal development wasn't right, the dental arches were not well-formed, teeth came in crowded - click here
In Search of the Ultimate Diet
I put a group of mice on a fruitarian diet. But they didn't seem to be eating very much fruit, and they certainly weren't crazy about it - click here
The Ideal 100% Raw Diet
My aim here was to try to find a diet of 100% raw foods that mice and equally humans could live on, with all the factors needed for excellent health - click here
Vegetarian Diet & Food Plan
Dr. Cursio: - it represents more than 55 years of this brilliant nutritionist's experience as one of the greatest teachers in the field of Natural Hygiene - click here
Vegan rats die early & have low energy
When the vegetarian male died it was 22.8 months old. The omnivorous male had accomplished the same amount of work when it was but 6.9 months old. click here


Primitive Man - His Diet and Health
The duration of life is long, the people being yet strong and vigorous as they pass the three score and ten mark, and living in many cases beyond a century. click here
Vilhjalmur Stefansson: Adventures in Diet
I have lived in the Arctic for more than five years exclusively on meat and water ... I tried the rotten fish one day, and liked it better than my first taste of Camembert. During the next weeks I became fond of rotten fish. click here
Aajonus: Primitive Diet Example
After 12 years eating raw meat and never having had any more than a little diarrhea, I learned to relax and not fear raw foodborne bacteria and parasites. click here
Dr. Shelton: How Much Protein?
There is a delicate balance between carbohydrates and proteins, to which we have to conform - disease and degeneration resulting from failure to conform. click here
Drs. Eades: High-Carbohydrate Problems
An anthropologist examining skeletal remains of early man can tell immediately whether the bones and teeth belonged to a hunter-gatherer (mainly protein eater) or a farmer (mainly carbohydrate eater)..." click here
Dr. Rosedale: Insulin's Metabolic Effects
The actual rate of aging can be modulated by insulin... We should be living to be 130, 140 years old routinely. click here  
Insulin's Crucial Role: insulin article 2   What is mTor? insulin article 3
Cancer & The Warburg Effect
The theory is simple: If most aggressive cancers rely on the fermentation of sugar for growing and dividing, then take away the sugar and they should stop spreading. click here
Swami Narayanananda: Food And Drink
Many sects and people have very crude ideas about food and drink. In India, some narrow-minded and bigoted people have much hatred for non-vegetarian diet. click here


The Ten Health Commandments
Thou shalt lift thyself up through obedience to all of Nature's laws, and help thy brother to attain the same. click here
The Truth Behind All Religion
God is not punishing us with illness and disease. Our suffering is due to our ignorance of food's relation to health and happiness. click here
Practicing with Certainty
People who are told they have emotional problems are suffering from thinking problems. Their emotions are working fine. click here
Vivekananda: Man's True Spiritual Nature
Let positive, strong, helpful thought enter into their brains from very childhood. Lay yourselves open to these thoughts, and not to weakening and paralysing ones. click here



If you are sick, read:
How Diseases are Cured
The Time-factor in Recovery
How Important is Diagnosis?
How to Live 100 Years
What Symptoms to Expect when Improving Your Diet
My First Water Fast

If you have a hard time changing habits, read:
Causes of Addiction to Habits
The Power of Habit Explained
How to Overcome Temptations

If you are suffering from depression or low energy, read:
Energy, Feeling and Thought
Energy in the Body

If you are trying to overcome an addiction, read:
Causes of Addiction to Habits
The Power of Habit Explained
How to Overcome Temptations
Energy, Feeling and Thought

If you are trying to lose weight, read:
(about low-carb + raw diets as the correct strategy:)

The High-Carbohydrate Diet and Related Health Problems
Insulin's Metabolic Effects (Why eat less carbohydrates?)
How much weight-loss on raw juices vs. fasting?
Preventing Cellulite - the Diet Solution
(about overcoming the physical 'sugar' craving:)
Causes of Addiction to Habits
What Symptoms to Expect when Improving Your Diet
(about the emotional battle:)
Attentive Eating
How to Overcome Temptations
Energy, Feeling and Thought

If you don't want to change your diet, but still become healthier, read:
Sequential Eating
How to Live 100 Years
Energy, Feeling and Thought
Energy in the Body

If you are looking for the ultimate vegetarian diet,
- or have been damaged by veganism - read:

With Three Generations of Vegetarian Hygienists
In Search of the Ultimate Vegetarian Diet
Fruit - Friend or Foe?
The Ideal 100% Raw Diet
Natural Hygiene Vegetarian Diet & Food Plan
Sequential Eating
What Symptoms to Expect when Improving Your Diet

If you are looking for a non-vegetarian diet that will give superior health:
Primitive Man - His Diet and Health
The High-Carbohydrate Diet and Related Health Problems
Insulin's Metabolic Effects (Why eat less carbohydrates?)
New Concepts in Nutrition, Health and Rapid Healing of Illness
Primitive Diet Example
Sequential Eating
What Symptoms to Expect when Improving Your Diet

If you expect or have children, read:
Birth Defects can be Avoided!
What You do when You Vaccinate
How Diseases are Cured

If you want a better sex-life, read:
Energy-Karezza - fascinating & powerful sex
Enjoying Superior Sex Your Entire Life - radio interview
Energy-Karezza book excerpt

If you are new to Natural Hygiene, read:
How Diseases are Cured
The Time-factor in Recovery
How Important is Diagnosis?
My First Water Fast
New Concepts in Nutrition, Health and Rapid Healing of Illness

Also read Drs. Eades:  High-Carbohydrate Problems - "For 700,000 years humans ate a diet of mainly meat, fat, nuts, and berries. Eight thousand years ago we learned to farm, and our health declined."

Also read:  Primitive Diet Example - interview with Aajonus Vonderplanitz. "After 12 years eating raw meat and never having had any more than a little diarrhea that might have been associated with it, I learned to relax and not fear raw foodborne bacteria and parasites. "

Also read:  How Important is Diagnosis? - "Even if a person has a baffling, rare disease and the diagnosis is unknown, if he or she eats properly, or fasts if necessary in addition, the body will surely heal itself, as long as sufficient vitality is present."

Don't miss this free download: - REMARKABLE RECOVERIES FROM SEVERE HEALTH PROBLEMS - Dr. Bass' booklet presenting how raw foods and juices have been used clinically in medical institutions for over 100 years to help patients recover from cancer and other diseases, even to improve intelligence.

This website is a good example of Natural Hygiene - a 150+ year old self-empowering healing and health philosophy that was started by medical doctors - but almost forgotten in the 20th century.
Learn why it is now becoming mainstream again. Learn more about why no-drugs healing methods are not only cheap, but vastly superior.
Visit the organization   International Natural Hygiene Society - where Dr. Bass is one of the founders.

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